What Is Pyrrole Disorder?

Yummy Doctor - What is Pyrrole Disorder

If You Have a Child with Autism Please Read This

Were you aware that 46-48% of children with autism have Pyrrole disorder, also known as Pyroluria?

Most know nothing about this disorder which is generally caused by the same assault that leads to autism and other nervous system damage: vaccines and other metals.

Pyroluria, or Pyrrole disorder, is a condition induced by stress (high cortisol). Individuals with this condition produce too much of kryptopyrrole, a by-product of hemoglobin synthesis. This kryptopyrrole binds to and depletes the body of vitamin B6, magnesium, and zinc, three nutrients involved in the production of neurotransmitters, gut health, and mood regulation. As such, deficiencies of these nutrients can eventually result in increased anxiety, cognitive issues, trouble sleeping, difficulties concentrating, and even nervous twitching. As you may have guessed, pyroluria is common in autism: it is estimated that 46 to 48% of children with autism also suffer from pyroluria

Looking into this more Pyrrole Disorder causes stimming, agitation, and typical autism behaviours.

Mental conditions that have been associated with pyroluria include:

• acute intermittent porphyria


• autism/Asperger’s

• rapid cycling bipolar disorder

• depression

• Down’s syndrome

• learning difficulties

• schizophrenia

• Tourette’s syndrome

• alcoholism

• also associated with violent and criminal behaviour and substance abuse

Pyrrole disorder can be diagnosed by a kryptopyrrole test (you can order this from Great Plains Labs – The urine test is $250 USD) which is designed to find elevated kryptopyrroles in urine. The Kryptopyrrole test carefully determines the levels of pyrroles the body excretes.

It is treatable with zinc, magnesium (topical) and certain types of vitamin B6: P5P (pyridoxal 5’ phosphate).

But here is some VERY important information that you have to dig deeper to find, people with pyrrole disorder often react poorly to Omega 3 and Omega 6 from fish oil, but not necessarily from other oils such as Evening Primrose oil or Borage oil.

Many children with autism are on fish oil/cod liver oil. Many kids with autism are not on a zinc supplement or a B6 supplement.

I don’t recommend anyone stops giving fish oil before getting test results as there are many benefits to omega 3 and 6.

You do not need to be on the autism spectrum to have pyrrole disorder, many people with ADHD also have it and so do many who have neither autism nor ADHD. This can be epigenetically acquired through environmental and emotional stress and especially from ‘leaky gut syndrome’.

This disorder can be treated with three supplements and dropping another (some people with Pyrrole Disorder are fine on fish oil and some are not).

If you have a child with autism, please consider doing this test. Very few people are even aware of this disorder. B6, magnesium, and zinc are ESSENTIAL for us to operate properly and people with pyrrole disorder need to take specific high doses of it. Essential means our bodies do not make this on their own. People with pyrrole do not absorb enough from food alone because: in order for B6 to be used by the body it must first be converted to pyridoxal 5’-phosphate (P5P), a process that takes place in the liver. Individuals with compromised liver function have difficulty making this conversion and consequently may be at risk of a vitamin B6 deficiency. Supplementing with Pyridoxal 5’-Phosphate ensures patients receive the most bioactive form of vitamin B6.

Also, copper levels should be about equal to zinc and often people with pyrrole disorder have high copper and low zinc. This is something that also can be tested for.

You can find supplements at https://yumnaturals.store and https://DMSO.store

Learn more about another epigenetic problem in those with autism, ADD, nervous system, digestive, and detox disorders – that of MTHFR mutation and how to compensate for those deficiencies:

Watch here: https://yummy.doctor/video-list/mthfr-gene-mutation-and-histamine-intolerance/

Recommended products:

Biotics Research Aqueous Zinc

YumNaturals ZEN Magnesium

Biotics Research Bio-B 100

Biomed B12 Folate MethylB12 MeF 60 Lozenges

Biotics Research TMG Powder – Trimethylglycine

More info on this disorder:


About Yummy.Doctor

Amandha D Vollmer
BSc, Herbalist, Reiki Master,
Holistic Health Practitioner,
Degree of Doctor of Naturopathic Medicine

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Posted on January 18, 2023 by Yummy.Doctor