How to use NATPRO Progesterone Cream

Yummy Doctor Holistic Health Education - Blog - How to use NATPRO Progesterone Cream
Yummy Doctor Holistic Health Education - Blog - How to use NATPRO Progesterone Cream

NOTE: The strength of progesterone creams vary from 1.5% to 10%. This means a 1.5% cream contains 15mg progesterone per gram (g) or millilitre (ml). A 10% cream contains 100mg per gram (g) or millilitre (ml). So dependant on the amount of progesterone required, the amount of cream must be taken into account. Natpro is a 3.3% cream, or contains 33.3mg per gram or ml. All information here is based on Natpro.

One of the first things to understand when first using progesterone is that it is not an overnight fix, it can take anything from 2-6 months, possibly longer, before positive results are achieved. Time and patience are needed!! One must expect all sorts of ‘strange things’ to take place as the body adjusts, only once progesterone has become the dominant hormone will things start to improve. Most of these ‘strange things’ are Estrogen Dominance symptoms.

So many progesterone creams and advice suggest using 20-40mg of progesterone cream daily, this is INCORRECT. Nothing less than 100mg/3ml per day is needed using a 3.33% cream. This will avoid adverse symptoms, more if symptoms are severe. Usually when first using progesterone cream more than 100mg per day is needed. If the amount that you are using is not working, or symptoms are worse, use more. Experiment, use the cream to suit you and your particular symptom. With some use, adverse symptoms often get worse before they get better!


(100 grams/3.5 oz per dispenser) –  one full pump delivers 1.5ml/50mg.  Minimum amount needed is 100mg per day which is two full pumps, more if symptoms are severe.

Learning how to use progesterone cream is not difficult for a woman once she understands it in relation to her cycle. 

For men it is even easier, any time, anywhere.

A woman’s cycles can vary from as little as 21 days to as long as 36, the average being 28 days. This is the reason why manufacturers of The Pill and HRT pack their product in 28 day batches.

The following guide is also based on 28 days, but please bear in mind that if your cycle is longer or shorter, follow that, rather than the average.

To give you some idea, all women, irrespective of the length of their cycle, should start ovulating 14 days before they start bleeding again.

This means that you should start using the cream either at ovulation, if you know when it happens, or 14 days before your next period is due. If you don’t ovulate or have a period, stick to the 28 day cycle, choosing any day to start.

– A 21 day cycle – Ovulation should occur on day 7
– A 28 day cycle – Ovulation should occur on day 14
– A 36 day cycle – Ovulation should occur on day 21

Many advise to start using progesterone cream on day 14, this is totally incorrect!

The cream should only be used from ovulation (Luteal Phase) for the last 14 days of the cycle in a menstruating woman

This is the key to understanding how to use progesterone cream. If used earlier than ovulation, it will prevent ovulation.   The idea behind the cream is to supplement the low level of endogenous progesterone i.e. what your body makes during the luteal phase.

The first day of the cycle is the first day of bleeding. There are some women who have what is known as a defective luteal phase, which means that they start bleeding again before the 14 days are up. A defective luteal phase is often the cause of a failed conception or miscarriage. If this is the case, using progesterone can help to lengthen it.

Supplemental progesterone usually stops food and alcohol cravings, depression, painful breasts, cramps, tiredness and anger that occur just prior to bleeding.

Please be aware that heavy bleeding/spotting/clotting could take place during the first month or two when first starting the cream. Don’t be alarmed, as it’s the progesterone cleaning out the lining that has built up in the uterus.

The cycle can also be disrupted when first using progesterone.  If spotting should occur, please ignore and continue using the cream. If a full period should occur early, discontinue the cream counting the first day of bleeding as day 1. Bleeding may also be delayed for a few days. When this occurs, count the first day of bleeding as day 1. Start using the cream again at ovulation or for the last 14 days of the cycle.

Please note: Stress drops progesterone levels sharply, so if you find symptoms returning it could be you’re going through a particularly stressful time. The reason for this is cortisol, the stress hormone, is made from progesterone. The stress response is a survival instinct, so the body will use any available progesterone and convert it into cortisol to overcome the stress, be it acute or chronic. You should increase the amount of progesterone you are using if symptoms return and then reduce it once the stressful period is over.

Menstruation should start within a day or two of stopping the progesterone

The amount of progesterone to use depends on symptoms and the severity of them.

Follicular phase – starts on the 1st day of bleeding and ends at ovulation.  No progesterone is used during this time.

Luteal phase – starts from ovulation until bleeding.  It is always, in all women, 12-14 days long.  Progesterone is used during this luteal phase.

For contraceptive purposes, deduct 5 to 8 days from the date of ovulation to start using progesterone. 

How to apply NATPRO Progesterone Cream

One of the key benefits of understanding how to use Natpro progesterone cream is that the cream can be applied anywhere –  in the vagina or nose for dryness, on piles, painful or achy areas, burns (its amazing on burns), insect bites and is wonderful on the face and so on.

Important to remember is that progesterone in the form of drops and tablets do not work as 96% of it is destroyed by the gut and liver.  The best application is by using cream, injections or suppositories!

Please note:

– do not use the cream on only one small patch of skin. Continual rubbing on one spot can lead to irritation and the cream will not absorb well either.
– Natpro progesterone cream takes about 5 minutes to absorb into the bloodstream, even hair follicles absorb it well, so it can be used anywhere.
– It’s best to rotate the area daily.
Natpro progesterone cream is best applied twice a day as levels start to drop after 13 hours.  It’s important to keep levels up, so split whatever daily dose is chosen, morning and again at night. Some women prefer to use more at night, less in the morning, but it’s up to the individual to experiment.

All the successful studies done on progesterone indicate between 100-200mg should be used each day. This equates to 3-6ml of a 3.33% concentration cream such as Natpro per day. Some studies used 400-600mg/day.  As much as 1200mg per day is used on patients suffering Traumatic Brain Injury (TBI) see here.  The late Dr Kittie Dalton used to give her patients suffering from psychosis 2400mg per day and 800mg for nausea.

In answering the question ‘how to use progesterone cream’ it must be made clear that there is actually no right or wrong way as it depends on what your adverse symptoms are.  The more severe the symptoms are, the more progesterone is needed until one feels stable enough to reduce.

What causes progesterone levels to drop?

I regularly receive messages from women who have been using progesterone for some time, stating that their symptoms have returned.  A lack of or a drop in vitamin D3 levels, even if a missed dose has taken place, or if lots of time has been spent indoors and not getting enough sun, affects our vitamin D3 levels, which in turn, affects progesterone levels. Stress destroys both progesterone and vitamin D3, amongst many other vital nutrients.

Some Main Reasons that could cause Progesterone levels to drop:

– lack of or drop in Vitamin D3 levels
– high estrogen
– high testosterone
– high LH
– high FSH sugars of any kind
– large meals
– alcohol
– stress
– insulin resistance
– high level of phytoestrogens in the diet

How to reduce NATPRO Progesterone Cream 

You can slowly start to reduce the amount of cream used once you feel stable enough to do so and ALL your adverse symptoms have cleared.  It is vital that this is done SLOWLY – if too much is reduced too soon, your symptoms will return. Should this happen, simply increase the amount of cream until you feel stable again and then try again by slowly reducing.  It is essential to reduce over a few weeks to prevent adverse symptoms returning.

How to Reduce – reduce by no more than 50mg. Stay on that reduced amount for a week, then reduce again by another 50mg and so on. Symptoms will return if you reduce by too much and too quickly.  NEVER reduce to less than 100mg/3ml per day as all adverse symptoms will return.

Heavy/Continual/Spotting – Bleeding Protocol

400-500mg NATPRO Progesterone Cream per day.

2000mg N-Acetyl-Cysteine (NAC) per day.

2000mg Taurine per day.

5000IU Vitamin D3 per day.  

Co-factors are vital when taking vitamin D3.

1000mg Bioflavanoids per day

Yummy Doctor Holistic Health Education - Blog - NATPRO Progesterone Cream
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Amandha D Vollmer
BSc, Herbalist, Reiki Master,
Holistic Health Practitioner,
Degree of Doctor of Naturopathic Medicine

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Posted on May 26, 2023 by Yummy.Doctor